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Design and optimization of a novel bio‐loom to weave melt‐spun absorbable polymers for bone tissue engineering
Author(s) -
Gilmore Jordon,
Burg Timothy,
Groff Richard E.,
Burg Karen J. L.
Publication year - 2017
Publication title -
journal of biomedical materials research part b: applied biomaterials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.665
H-Index - 108
eISSN - 1552-4981
pISSN - 1552-4973
DOI - 10.1002/jbm.b.33700
Subject(s) - weaving , tissue engineering , loom , materials science , biomedical engineering , electrospinning , ultimate tensile strength , biocompatible material , computer science , composite material , mechanical engineering , polymer , engineering
Bone graft procedures are currently among the most common surgical procedures performed worldwide, but due to high risk of complication and lack of viable donor tissue, there exists a need to develop alternatives for bone defect healing. Tissue engineering, for example, combining biocompatible scaffolds with mesenchymal stem cells to achieve new bone growth, is a possible solution. Recent work has highlighted the potential for woven polymer meshes to serve as bone tissue engineering scaffolds; since, scaffolds can be iteratively designed by adjusting weave settings, material types, and mesh parameters. However, there are a number of material and system challenges preventing the implementation of such a tissue engineering strategy. Fiber compliance, tensile strength, brittleness, cross‐sectional geometry, and size present specific challenges for using traditional textile weaving methods. In the current work, two potential scaffold materials, melt‐spun poly‐ l ‐lactide, and poly‐ l ‐lactide‐ co ‐ε‐caprolactone, were investigated. An automated bio‐loom was engineered and built to weave these materials. The bio‐loom was used to successfully demonstrate the weaving of these difficult‐to‐handle fiber types into various mesh configurations and material combinations. The dobby‐loom design, adapted with an air jet weft placement system, warp tension control system, and automated collection spool, provides minimal damage to the polymer fibers while overcoming the physical constraints presented by the inherent material structure. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 105B: 1342–1351, 2017.