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Toward a skin‐material interface with vacuum‐integrated capped macroporous scaffolds
Author(s) -
Stynes Gil D.,
Kiroff George K.,
Morrison Wayne A.,
Page Richard S.,
Kirkland Mark A.
Publication year - 2017
Publication title -
journal of biomedical materials research part b: applied biomaterials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.665
H-Index - 108
eISSN - 1552-4981
pISSN - 1552-4973
DOI - 10.1002/jbm.b.33649
Subject(s) - materials science , biomedical engineering , scaffold , epidermis (zoology) , fibroin , artificial skin , biocompatible material , composite material , anatomy , medicine , silk
Avulsion, epidermal marsupialization, and infection cause failure at the skin‐material interface. A robust interface would permit implantable robotics, prosthetics, and other medical devices; reconstruction of surgical defects, and long‐term access to blood vessels and body cavities. Torus‐shaped cap‐scaffold structures were designed to work in conjunction with negative pressure to address the three causes of failure. Six wounds were made on the backs of each of four 3‐month old pigs. Four unmodified (no caps) scaffolds were implanted along with 20 cap‐scaffolds. Collagen type 4 was attached to 21 implants. Negative pressure then was applied. Structures were explanted and assessed histologically at day 7 and day 28. At day 28, there was close tissue apposition to scaffolds, without detectable reactions from defensive or interfering cells. Three cap‐scaffolds explanted at day 28 showed likely attachment of epidermis to the cap or cap‐scaffold junction, without deeper marsupialization. The combination of toric‐shaped cap‐scaffolds with negative pressure appears to be an intrinsically biocompatible system, enabling a robust skin‐material interface. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 105B: 1307–1318, 2017.