Premium
Polymer degradation and drug delivery in PLGA ‐based drug–polymer applications: A review of experiments and theories
Author(s) -
Xu Yihan,
Kim ChangSoo,
Saylor David M.,
Koo Donghun
Publication year - 2017
Publication title -
journal of biomedical materials research part b: applied biomaterials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.665
H-Index - 108
eISSN - 1552-4981
pISSN - 1552-4973
DOI - 10.1002/jbm.b.33648
Subject(s) - plga , polymer , drug , drug delivery , biodegradable polymer , degradation (telecommunications) , materials science , polymer degradation , copolymer , nanotechnology , computer science , pharmacology , composite material , nanoparticle , medicine , telecommunications
Poly (lactic‐co‐glycolic acid) (PLGA) copolymers have been broadly used in controlled drug release applications. Because these polymers are biodegradable, they provide an attractive option for drug delivery vehicles. There are a variety of material, processing, and physiological factors that impact the degradation rates of PLGA polymers and concurrent drug release kinetics. This work is intended to provide a comprehensive and collective review of the physicochemical and physiological factors that dictate the degradation behavior of PLGA polymers and drug release from contemporary PLGA‐based drug–polymer products. In conjunction with the existing experimental results, analytical and numerical theories developed to predict drug release from PLGA‐based polymers are summarized and correlated with the experimental observations. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 105B: 1692–1716, 2017.