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Tumor homing indocyanine green encapsulated micelles for near infrared and photoacoustic imaging of tumors
Author(s) -
Uthaman Saji,
Bom Joonsuk,
Kim Hyeon Sik,
John Johnson V.,
Bom HeeSeung,
Kim SeonJong,
Min JungJoon,
Kim Il,
Park InKyu
Publication year - 2016
Publication title -
journal of biomedical materials research part b: applied biomaterials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.665
H-Index - 108
eISSN - 1552-4981
pISSN - 1552-4973
DOI - 10.1002/jbm.b.33607
Subject(s) - indocyanine green , micelle , hyaluronic acid , photoacoustic imaging in biomedicine , in vivo , chemistry , biomedical engineering , imaging agent , preclinical imaging , cancer research , materials science , medicine , pathology , aqueous solution , biology , optics , anatomy , physics , microbiology and biotechnology
Photoacoustic imaging (PAI) is an emerging analytical modality that is under intense preclinical development for the early diagnosis of various medical conditions, including cancer. However, the lack of specific tumor targeting by various contrast agents used in PAI obstructs its clinical applications. In this study, we developed indocyanine green (ICG)‐encapsulated micelles specific for the CD 44 receptor and used in near infrared and photoacoustic imaging of tumors. ICG was hydrophobically modified prior to loading into hyaluronic acid (HA)‐based micelles utilized for CD 44 based‐targeting. We investigated the physicochemical characteristics of prepared HA only and ICG‐encapsulated HA micelles (HA‐ICG micelles). After intravenous injection of tumor‐bearing mice, the bio‐distribution and in vivo photoacoustic images of ICG‐encapsulated HA micelles accumulating in tumors were also investigated. Our study further encourages the application of this HA‐ICG‐based nano‐platform as a tumor‐specific contrast agent for PAI. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 104B: 825–834, 2016.