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Preparation of silicon‐modified antimicrobial polyethylene endotracheal tubes
Author(s) -
Jiang Xuhong,
Lv Bin,
Shen Qianhong,
Wang Xinmin
Publication year - 2017
Publication title -
journal of biomedical materials research part b: applied biomaterials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.665
H-Index - 108
eISSN - 1552-4981
pISSN - 1552-4973
DOI - 10.1002/jbm.b.33530
Subject(s) - polyethylene , antimicrobial , materials science , endotracheal tube , composite material , chemistry , medicine , organic chemistry , surgery , intubation
Antimicrobial coating of polyethylene endotracheal tubes (PE ETTs) has proven to be an effective method to prevent endoluminal biofilm formation. A transparent silicon‐modified antimicrobial PE ETT was obtained by coating PE with a SiO 2 /γ‐methacryloxypropyl trimethoxy silane (KH‐570)/methyltriethoxysilane (MTES)/Ag‐SiO 2 solution prepared by chemically mixing Ag‐SiO 2 with SiO 2 /KH‐570/MTES in solution via a dip‐coating method, with tetraethyl orthosilicate (TEOS) as the inorganic silicon source, followed by drying. All the films were characterized by various techniques, including the pencil hardness test, infrared spectroscopy, scanning electron microscopy, UV–vis analysis, and inductively coupled plasma mass spectrometry (ICP‐MS). The results indicated that the TEOS/KH‐570/MTES/Ag‐SiO 2 (15:6:1:0.6–1.0) films, which exhibited simple in‐solution film formation on PE ETTs, had a homogeneous morphology, high transmittance above 87%, high hardness of 5H and strong adhesion to the tubes. The concentration of Ag + ion dissolved out from the antibacterial coating is very low in ICP‐MS results. The antibacterial test results show that the antibacterial coatings have excellent antibacterial property with antibacterial ratio up to 93.5% when Ag‐SiO 2 content is 2.6%. In pyrogen test and hemolytic test, the body temperature of rabbits rise 0.03°c for 3 h after inserting antibacterial PE ETT, and the hemolytic ratio is 0.7512%, which conform to the requirements of biomedical material. The results preliminarily proved that the antibacterial materials could be a good candidate of medical catheter material application or medical device surface coating materials. © 2015 The Authors. Journal of Biomedical Materials Research Part B: Applied Biomaterials published by Wiley Periodicals, Inc. 105B: 91–98, 2017.