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Lithium‐doped β‐tricalcium phosphate: Effects on physical, mechanical and in vitro osteoblast cell–material interactions
Author(s) -
Vahabzadeh Sahar,
Hack Vaughn Kohsei,
Bose Susmita
Publication year - 2017
Publication title -
journal of biomedical materials research part b: applied biomaterials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.665
H-Index - 108
eISSN - 1552-4981
pISSN - 1552-4973
DOI - 10.1002/jbm.b.33485
Subject(s) - doping , osteoblast , in vitro , materials science , phosphate , lithium (medication) , chemistry , biochemistry , medicine , optoelectronics
In this work, we have investigated the effects of lithium (Li) dopant at different concentrations and sintering temperatures on the physical and mechanical properties of β‐tricalcium phosphate (β‐TCP). Our results showed that Li addition at concentrations of 0.65 and 1.0 wt % inhibits the β‐TCP to α‐TCP phase transformation. 0.15 wt % Li addition resulted in grain growth and extensive liquid phase was formed at higher concentrations. At 1150°C, compressive strength of β‐TCP increased from 138.7 ± 19.9 MPa to 170.9 ± 29.8 MPa with the addition of 0.15 wt % Li. Addition of higher amounts of Li decreased the compressive strength and the lowest compressive strength of 99.8 ± 13.7 MPa was found in samples containing 1.0 wt % Li. After 3 days of culture, osteoblast cells grew to confluence on samples containing 0.65 and 1.0 wt % Li. Cells grew to confluence on all doped samples after 11 days of culture and optical cell density was 4–5 folds higher on 0.15 and 1.0 wt % Li‐doped TCP samples. Our results show that both Li content and sintering temperature have significant influence toward physicochemical and mechanical properties of β‐TCP which affects the osteoblast cell–materials interaction in Li‐doped TCP scaffolds. © 2015 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 105B: 391–399, 2017.