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Fe–Au and Fe–Ag composites as candidates for biodegradable stent materials
Author(s) -
Huang Tao,
Cheng Jian,
Bian Dong,
Zheng Yufeng
Publication year - 2016
Publication title -
journal of biomedical materials research part b: applied biomaterials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.665
H-Index - 108
eISSN - 1552-4981
pISSN - 1552-4973
DOI - 10.1002/jbm.b.33389
Subject(s) - materials science , spark plasma sintering , microstructure , scanning electron microscope , powder metallurgy , corrosion , composite material , compressive strength , electrochemistry , optical microscope , sintering , metallurgy , electrode , chemistry
Abstract In this study, Fe–Ag and Fe–Au composites were fabricated by powder metallurgy using spark plasma sintering. Their microstructures, mechanical properties, and biocorrosion behavior were investigated by using optical microscopy, X‐ray diffraction, environment scanning electronic microscopy, compressive test, electrochemical measurements, and immersion tests. Microstructure characterization indicated that the as‐sintered iron‐based materials obtained much finer grains than that of as‐cast pure iron. Phase analysis showed that the Fe–Ag composites were composed of α‐Fe and pure Ag phases, and Fe–Au composites consisted of α‐Fe and Au phases. Compressive test showed that the improved mechanical strengths were obtained in as‐sintered iron‐based materials, among which the Fe‐5 wt %Ag exhibited the best mechanical properties. The electrochemical and immersion tests revealed that the addition of Ag and Au could increase the corrosion rate of the iron matrix and change the corrosion mode into more uniform one. Based on the results of cytotoxicity evaluation, it was found that all the experimental material extracts performed no significant toxicity on the L‐929 cells and EA. hy‐926 cells, whereas a considerable inhibition on the proliferation of vascular smooth muscle cells was observed. The hemocompatibility tests showed that the hemolysis of all the experimental materials was within the range of 5%, which is the criteria value of biomaterials with good hemocomaptibility. The amount of platelet adhered on the surface of as‐sintered iron‐based materials was lower than that of as‐cast pure iron, and the morphology of platelets kept smoothly spherical on the surface of all the experimental materials. © 2015 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 104B: 225–240, 2016.