Premium
Gene delivery in tissue engineering and regenerative medicine
Author(s) -
Fang Y. L.,
Chen X. G.,
W. T. Godbey
Publication year - 2015
Publication title -
journal of biomedical materials research part b: applied biomaterials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.665
H-Index - 108
eISSN - 1552-4981
pISSN - 1552-4973
DOI - 10.1002/jbm.b.33354
Subject(s) - regenerative medicine , ex vivo , tissue engineering , gene delivery , stem cell , induced pluripotent stem cell , transplantation , embryonic stem cell , biology , in vivo , regeneration (biology) , microbiology and biotechnology , genetic enhancement , biomedical engineering , gene , medicine , surgery , genetics
As a promising strategy to aid or replace tissue/organ transplantation, gene delivery has been used for regenerative medicine applications to create or restore normal function at the cell and tissue levels. Gene delivery has been successfully performed ex vivo and in vivo in these applications. Excellent proliferation capabilities and differentiation potentials render certain cells as excellent candidates for ex vivo gene delivery for regenerative medicine applications, which is why multipotent and pluripotent cells have been intensely studied in this vein. In this review, gene delivery is discussed in detail, along with its applications to tissue engineering and regenerative medicine. A definition of a stem cell is compared to a definition of a stem property, and both provide the foundation for an in‐depth look at gene delivery investigations from a germ lineage angle. © 2014 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 103B: 1679–1699, 2015.