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Electrodeposited silk coatings for bone implants
Author(s) -
Elia Roberto,
Michelson Courtney D.,
Perera Austin L.,
Brunner Teresa F.,
Harsono Masly,
Leisk Gray G.,
Kugel Gerard,
Kaplan David L.
Publication year - 2015
Publication title -
journal of biomedical materials research part b: applied biomaterials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.665
H-Index - 108
eISSN - 1552-4981
pISSN - 1552-4973
DOI - 10.1002/jbm.b.33351
Subject(s) - materials science , silk , coating , adhesive , composite material , titanium , dissolution , surface roughness , biomedical engineering , chemical engineering , metallurgy , layer (electronics) , engineering , medicine
The aim of this study was to characterize the mechanical properties and drug elution features of silk protein‐based electrodeposited dental implant coatings. Silk processing conditions were modified to obtain coatings with a range of mechanical properties on titanium studs. These coatings were assessed for adhesive strength and dissolution, with properties tuned using water vapor annealing or glycerol incorporation to modulate crystalline content. Coating reproducibility was demonstrated over a range of silk concentrations from 1% to 10%. Surface roughness of titanium substrates was altered using industry relevant acid etching and grit blasting, and the effect of surface topography on silk coating adhesion was assessed. Florescent compounds were incorporated into the silk coatings, which were modulated for crystalline content, to achieve four days of sustained release of the compounds. This silk electrogelation technique offers a safe and relatively simple approach to generate mechanically robust, biocompatible, and degradable implant coatings that can also be functionalized with bioactive compounds to modulate the local regenerative tissue environment. © 2014 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 103B: 1602–1609, 2015.