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Vertical bone augmentation induced by ultrathin hydroxyapatite sputtered coated mini titanium implants in a rabbit calvaria model
Author(s) -
Wang Xin,
Zakaria Osama,
Madi Marwa,
Hao Jia,
Chou Joshua,
Kasugai Shohei
Publication year - 2015
Publication title -
journal of biomedical materials research part b: applied biomaterials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.665
H-Index - 108
eISSN - 1552-4981
pISSN - 1552-4973
DOI - 10.1002/jbm.b.33347
Subject(s) - calvaria , implant , titanium , dentistry , bone formation , materials science , osseointegration , biomedical engineering , chemistry , medicine , surgery , in vitro , metallurgy , biochemistry
Background The purpose of this study was to evaluate the vertical new bone formation induced by sputtered HA‐coated titanium implants (HA‐coated) compared with sandblasted acid‐etched titanium implants (noncoated) in a rabbit calvarial model. Materials and method Twenty HA‐coated and 20 noncoated titanium implants were divided equally into four groups as HA‐coated implant (HA); noncoated implant (NC); HA‐coated implant with membrane (HA/M); noncoated implant with membrane (NC/M). All implants were placed 5 mm above the original bone (OB). Collagen membranes were placed over the implants in HA/M and NC/M groups. The animals were sacrificed at 4 weeks ( n = 5) and 8 weeks ( n = 5). Vertical bone height above OB (VBH, mm) and augmented bone area (ABA, mm 2 ) were analyzed histologically and radiographically. Results At 4 weeks, VBH reached significantly higher level in HA/M group compared with other three groups ( p < 0.05). At 8 weeks, significant difference was detected between HA/M and NC groups ( p < 0.05). At 4 and 8 weeks, ABA in HA/M group was significantly larger compared with other three groups ( p < 0.05). Conclusion The present results indicated that sputtered HA‐coated titanium implant together with collagen membrane could be a novel and effective approach for vertical bone augmentation. © 2014 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 103B: 1700–1708, 2015.