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Enhanced osseointegration of endosseous implants by predictable sustained release properties of strontium
Author(s) -
Offermanns Vincent,
Andersen Ole Zoffmann,
Falkensammer Gottfried,
Andersen Inge Hald,
Almtoft Klaus Pagh,
Sørensen Søren,
Sillassen Michael,
Jeppesen Christian Sloth,
Rasse Michael,
Foss Morten,
Kloss Frank
Publication year - 2015
Publication title -
journal of biomedical materials research part b: applied biomaterials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.665
H-Index - 108
eISSN - 1552-4981
pISSN - 1552-4973
DOI - 10.1002/jbm.b.33279
Subject(s) - osseointegration , strontium , titanium , implant , materials science , endosseous implants , dentistry , coating , in vivo , biomedical engineering , sputter deposition , nuclear chemistry , chemistry , sputtering , composite material , metallurgy , nanotechnology , surgery , medicine , thin film , microbiology and biotechnology , organic chemistry , biology
Studies have shown that strontium (Sr) incorporated into surfaces may enhance osseointegration. Thus, we suggested that a sustained Sr release from implant surfaces could improve bone healing. This study verifies and further investigates the effect of a novel TiSrO functionalized implant surface prepared from a magnetron co‐sputtering platform with a continuous release of Sr. Materials and methods Four experimental TiSrO groups, which differed from each other in Sr contents and pre‐wash procedures, were tested. Implants were prepared with a TiSrO coating by means of magnetron co‐sputtering and compared to Grade 4 titanium. Composition, morphology and mechanical stability were analyzed; Sr‐release data were gained from in vitro washout experiments. In vivo investigations were carried out in a rat model and analyzed histologically regarding bone‐to‐implant contact and new bone formation 30 days after implantation. Results Structural differences were detected between the two basis TiSrO coatings with 6.7 at.% and 8.9 at.% Sr, respectively. Different release profiles were observed with 8.9 at.% Sr coating exhibiting the highest long‐term release of Sr. Median values of new bone formation and bone‐to‐implant contact was found to be 60.1% and 91.6%, respectively, for the best group compared to 16.6% and 70.6% for the Grade 4 titanium reference. The increase in new bone formation was found to correlate with the amount of Sr released in vitro . Conclusion The results show that sputtered TiSrO coatings with sustained release of Sr may improve osseointegration, and could thus have impact on practical applications for medical implants. © 2014 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 103B: 1099–1106, 2015.