Premium
Tissue engineering bioreactor systems for applying physical and electrical stimulations to cells
Author(s) -
Jin GyuHyun,
Yang GiHoon,
Kim GeunHyung
Publication year - 2015
Publication title -
journal of biomedical materials research part b: applied biomaterials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.665
H-Index - 108
eISSN - 1552-4981
pISSN - 1552-4973
DOI - 10.1002/jbm.b.33268
Subject(s) - bioreactor , stimulation , tissue engineering , biomedical engineering , in vivo , microbiology and biotechnology , cell , cell growth , cell type , biochemical engineering , biophysics , materials science , chemistry , biology , neuroscience , medicine , engineering , biochemistry , organic chemistry
Bioreactor systems in tissue engineering applications provide various types of stimulation to mimic the tissues in vitro and in vivo . Various bioreactors have been designed to induce high cellular activities, including initial cell attachment, cell growth, and differentiation. Although cell‐stimulation processes exert mostly positive effects on cellular responses, in some cases such stimulation can also have a negative effect on cultured cells. In this review, we discuss various types of bioreactor and the positive and negative effects of stimulation (physical, chemical, and electrical) on various cultured cell types. © 2014 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 103B: 935–948, 2015.