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A mini‐review: Cell response to microscale, nanoscale, and hierarchical patterning of surface structure
Author(s) -
Jeon HoJun,
Simon Carl G.,
Kim GeunHyung
Publication year - 2014
Publication title -
journal of biomedical materials research part b: applied biomaterials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.665
H-Index - 108
eISSN - 1552-4981
pISSN - 1552-4973
DOI - 10.1002/jbm.b.33158
Subject(s) - microscale chemistry , nanoscopic scale , nanotechnology , materials science , pillar , fabrication , groove (engineering) , surface (topology) , mechanical engineering , geometry , engineering , medicine , mathematics education , mathematics , alternative medicine , pathology , metallurgy
Abstract Cellular behavior can be influenced by the chemical and physical surface characteristics of biomedical substrates. To understand the relationships between various topographical surface patterns and cellular activities, various types of pattern models have been developed and examined in a range of sizes (microscale, nanoscale, and hierarchical structures consisting of both) and shapes (pillar, hole, groove, grate, grid, and island). Here, we review fabrication methods for obtaining physically patterned microscale and nanoscale surfaces, and discuss the relationships between cellular responses and physically patterned surfaces, which could be applied to various biomedical scaffolds used in tissue engineering applications. © 2014 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 102B: 1580–1594, 2014.