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Modeling of time dependent localized flow shear stress and its impact on cellular growth within additive manufactured titanium implants
Author(s) -
Zhang Ziyu,
Yuan Lang,
Lee Peter D.,
Jones Eric,
Jones Julian R.
Publication year - 2014
Publication title -
journal of biomedical materials research part b: applied biomaterials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.665
H-Index - 108
eISSN - 1552-4981
pISSN - 1552-4973
DOI - 10.1002/jbm.b.33146
Subject(s) - scaffold , materials science , shear stress , porosity , titanium , biomedical engineering , flow (mathematics) , fluid dynamics , bone growth , shear (geology) , bone formation , nanotechnology , computer science , composite material , mechanics , engineering , physics , metallurgy , medicine , endocrinology
Bone augmentation implants are porous to allow cellular growth, bone formation and fixation. However, the design of the pores is currently based on simple empirical rules, such as minimum pore and interconnects sizes. We present a three‐dimensional (3D) transient model of cellular growth based on the Navier – Stokes equations that simulates the body fluid flow and stimulation of bone precursor cellular growth, attachment , and proliferation as a function of local flow shear stress. The model's effectiveness is demonstrated for two additive manufactured (AM) titanium scaffold architectures. The results demonstrate that there is a complex interaction of flow rate and strut architecture, resulting in partially randomi z ed structures having a preferential impact on stimulating cell migration in 3D porous structures for higher flow rates. This novel result demonstrates the potential new insights that can be gained via the modeling tool developed, and how the model can be used to perform what‐if simulations to design AM structures to specific functional requirements. © 2014 The Authors. Journal of Biomedical Materials Research Part B: Applied Biomaterials Published by Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 102B: 1689–1699, 2014.