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Fabrication of a heparin–PVA complex hydrogel for application as a vascular access
Author(s) -
Negishi Jun,
Nam Kwangwoo,
Kimura Tsuyoshi,
Hashimoto Yoshihide,
Funamoto Seiichi,
Higami Tetsuya,
Fujisato Toshiya,
Kishida Akio
Publication year - 2014
Publication title -
journal of biomedical materials research part b: applied biomaterials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.665
H-Index - 108
eISSN - 1552-4981
pISSN - 1552-4973
DOI - 10.1002/jbm.b.33121
Subject(s) - heparin , materials science , vinyl alcohol , fabrication , self healing hydrogels , biomedical engineering , polymer , vascular graft , chemical engineering , polymer chemistry , composite material , chemistry , medicine , alternative medicine , pathology , engineering , biochemistry
A high hydrostatic pressure method, which can apply over 600 MPa pressure was employed for preparing a hydrogel of poly(vinyl alcohol) (PVA) loaded with heparin. The aim of this study was to fabricate a heparin–PVA hydrogel conduit and evaluate its potential for vascular access. Heparin–PVA complex hydrogel showed suppressed heparin release and prevented clot formation, depending on the molecular weight of the PVA. Strength of the hydrogel conduit was increased by embedding a Dacron ® mesh between two PVA layers. The tubular heparin–PVA complex hydrogel displayed a burst pressure of 750 mmHg. The tubular heparin–PVA complex hydrogel did not show any occlusion or burst for 2 weeks after implantation, implying that this heparin–PVA complex hydrogel shows high potential for use as a vascular access. This is the first report on the preparation of a multilayered PVA hydrogel with heparin embedded on one side only. The proposed approach could be expanded to the fabrication of various biomaterials for specific purposes. © 2014 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 102B: 1426–1433, 2014.