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Critical analysis of cyanoacrylate in intestinal and colorectal anastomosis
Author(s) -
Wu Zhouqiao,
Boersema Geesien S. A.,
Vakalopoulos Konstantinos A.,
Daams Freek,
Sparreboom Cloe L.,
Kleinrensink GertJan,
Jeekel Johannes,
Lange Johan F.
Publication year - 2014
Publication title -
journal of biomedical materials research part b: applied biomaterials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.665
H-Index - 108
eISSN - 1552-4981
pISSN - 1552-4973
DOI - 10.1002/jbm.b.33039
Subject(s) - anastomosis , cyanoacrylate , meta analysis , colorectal surgery , web of science , medicine , general surgery , surgery , materials science , nanotechnology , adhesive , layer (electronics) , abdominal surgery
Background Although cyanoacrylate glue (CA) has been widely used in various kinds of medical applications, its application in gastrointestinal anastomosis remains limited, and outcomes of experimental studies have not been satisfactory. This systematic review summarizes research regarding CA application in intestinal and colorectal anastomosis, and correlates methodological aspects to experimental outcomes. Methods A systematic literature search was performed using Medline, Embase, Cochrane, and Web‐of‐Science libraries. Articles were selected if CA was applied to intestinal or colorectal anastomoses. Included articles were categorized according to CA molecular structure; the method details in each study were extracted and analyzed. Results Twenty‐two articles were included. More than half of the inclusions reported positive outcomes (seven articles) or neutral outcomes (eight articles). Analysis of the methods revealed that methodological details such as CA dosage, time of polymerization were not consistently reported. Porcine studies, inverted anastomosis, and n ‐butyl‐cyanoacrylate studies showed more positive outcomes; everted anastomosis, and oversized sutures might negatively influence the outcomes. Conclusions Owing to the positive outcome from the porcine studies, application of CA in gastrointestinal (GI) anastomosis still seems promising. To achieve a better consistency, more methodological details need to be provided in future studies. Optimizing the dosage of CA, choice of animal model, inverted anastomosis construction, and other method details may improve intestinal and colorectal anastomoses with CA application in future studies. © 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 102B: 635–642, 2014.