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Hydrothermal fabrication of ZSM‐5 zeolites: Biocompatibility, drug delivery property, and bactericidal property
Author(s) -
Guo YaPing,
Long Teng,
Song ZhenFu,
Zhu ZhenAn
Publication year - 2014
Publication title -
journal of biomedical materials research part b: applied biomaterials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.665
H-Index - 108
eISSN - 1552-4981
pISSN - 1552-4973
DOI - 10.1002/jbm.b.33037
Subject(s) - biocompatibility , drug delivery , materials science , zsm 5 , staphylococcus epidermidis , gentamicin , biomedical engineering , hydrothermal circulation , chemical engineering , nanotechnology , zeolite , chemistry , staphylococcus aureus , antibiotics , medicine , bacteria , organic chemistry , catalysis , biology , engineering , metallurgy , genetics , biochemistry
The bone graft‐associated infection is widely considered in orthopedic surgery, which may lead to implant failure, extensive bone debridement, and increased patient morbidity. In this study, we fabricated ZSM‐5 zeolites for drug delivery systems by hydrothermal method. The structure, morphology, biocompatibility, drug delivery property, and bactericidal property of the ZSM‐5 zeolites were investigated. The ZSM‐5 zeolites have mordenite framework inverted‐type structure and exhibit the disk‐like shape with the diameter of ∼350 nm and thickness of ∼165 nm. The biocompatibility tests indicate that human bone marrow stromal cells spread out well on the surfaces of the ZSM‐5 zeolites and proliferate significantly with increasing culture time. As compared with the conventional hydroxyapatite particles, the ZSM‐5 zeolites possess greater drug loading efficiency and drug sustained release property because of the ordered micropores, large Brunauer‐Emmett‐Teller (BET) surface areas, and functional groups. For the gentamicin‐loaded ZSM‐5 zeolites, the sustained release of gentamicin minimizes significantly bacterial adhesion and prevents biofilm formation against Staphylococcus epidermidis . The excellent biocompatibility, drug delivery property, and bactericidal property of the ZSM‐5 zeolites suggest that they have great application potentials for treating implant‐associated infections. © 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 102B: 583–591, 2014.