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Synthesis of mesoporous silica nanoparticle‐encapsulated alginate microparticles for sustained release and targeting therapy
Author(s) -
Liao YuTe,
Wu Kevin C.W.,
Yu Jiashing
Publication year - 2014
Publication title -
journal of biomedical materials research part b: applied biomaterials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.665
H-Index - 108
eISSN - 1552-4981
pISSN - 1552-4973
DOI - 10.1002/jbm.b.33007
Subject(s) - materials science , mesoporous silica , rhodamine 6g , drug delivery , nanoparticle , chromatography , nanotechnology , chemical engineering , mesoporous material , chemistry , organic chemistry , catalysis , molecule , engineering
This study reports the synthesis of mesoporous silica nanoparticle‐encapsulated alginate microparticles (MSN@Alg) for sustained release and targeting therapy. The MSN@Alg was synthesized by air dynamical atomization, and the effects of several critical factors including concentration of alginate solution, flow rate of alginate solution, flow rate of air, the distance between nozzle and calcium bath, and stirring rate of calcium on the particle size of the synthesized MSN@Alg were investigated. For studying the sustained release properties of the MSN@Alg, rhodamine 6G (R6G) was used as a model drug, and we compared the release properties of R6G/MSN and R6G/MSN@Alg using different concentrations of alginate, concentrations and volumes of phosphate‐buffered saline (PBS) buffer solutions. The sustained release behavior of the R6G/MSN@Alg system can be prolonged to 20 days with an optimal condition of 1 mg R6G/MSN@Alg to 2 mL PBS (10 m M ). To achieve targeting therapy, an anticancer drug, doxorubicin (Dox), was loaded into MSN@Alg, and a arginine, glycine, and aspartic acid (RGD)‐based peptide was functionalized onto the surface of MSN@Alg for the purpose of specific targeting. The results showed that the intracellular drug delivery efficiency was greatly enhanced (i.e., 3.5‐folds) for the Dox/MSN@Alg‐RGD drug delivery system. © 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 102B: 293–302, 2014.