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Osteocyte density in the peri‐implant bone of implants retrieved after different time periods (4 weeks to 27 years)
Author(s) -
Piattelli Adriano,
Artese Luciano,
Penitente Enrico,
Iaculli Flavia,
Degidi Marco,
Mangano Carlo,
Shibli Jamil Awad,
Coelho Paulo G,
Perrotti Vittoria,
Iezzi Giovanna
Publication year - 2014
Publication title -
journal of biomedical materials research part b: applied biomaterials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.665
H-Index - 108
eISSN - 1552-4981
pISSN - 1552-4973
DOI - 10.1002/jbm.b.33000
Subject(s) - osteocyte , implant , materials science , bone density , in vivo , bone remodeling , biomedical engineering , dentistry , medicine , surgery , biology , in vitro , osteoblast , osteoporosis , biochemistry , microbiology and biotechnology
Bone tissue is characterized by a constant turnover in response to mechanical stimuli, and osteocytes play an essential role in bone mechanical adaptation. However, little to no information has been published regarding osteocyte density as a function of implantation time in vivo . The aim of this retrospective histological study was to evaluate the osteocyte density of the peri‐implant bone in implants retrieved because of different reasons in a time period from 4 weeks to 27 years. A total of 18 samples were included in the present study. Specimens were divided into 3 groups depending on the loading history of the implants: loading between 4 weeks and 7 months (group 1); loading between 1 and 5 years (group 2); loading between 14 and 27 years (group 3). All the samples were histologically evaluated and osteocyte density was obtained using the ratio of the number of osteocytes to the bone‐area (mm 2 ). The osteocyte density values significantly increased in the Group 2 (1–5 years) compared with Group 1 (4 weeks–7 months), and significantly decreased in the Group 3 (14–27 years) compared to Group 2. No significant differences were detected between Group 1 and Group 3. The decrease in osteocyte density observed in samples that were in vivo for long periods of time under loading is possibly because of the fact that once the bone structure is well aligned and biomechanically competent, a lower number of osteocytes are necessary to keep the tissue homeostasis under loading. © 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 102B: 239–243, 2014.