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Improvement of the compressive strength of a cuttlefish bone‐derived porous hydroxyapatite scaffold via polycaprolactone coating
Author(s) -
Kim BeomSu,
Kang Hyo Jin,
Lee Jun
Publication year - 2013
Publication title -
journal of biomedical materials research part b: applied biomaterials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.665
H-Index - 108
eISSN - 1552-4981
pISSN - 1552-4973
DOI - 10.1002/jbm.b.32943
Subject(s) - compressive strength , polycaprolactone , porosity , coating , scaffold , materials science , composite material , biomedical engineering , engineering , polymer
Abstract Cuttlefish bones (CBs) have emerged as attractive biomaterials because of their porous structure and components that can be converted into hydroxyapatite (HAp) via a hydrothermal reaction. However, their brittleness and low strength restrict their application in bone tissue engineering. Therefore, to improve the compressive strength of the scaffold following hydrothermal conversion to a HAp form of CB (CB‐HAp), the scaffold was coated using a polycaprolactone (PCL) polymer at various concentrations. In this study, raw CB was successfully converted into HAp via a hydrothermal reaction. We then evaluated their surface properties and composition by scanning electron microscopy and X‐ray diffraction analysis. The CB‐HAp coated with PCL showed improved compressive performance and retained a microporous structure. The compressive strength was significantly increased upon coating with 5 and 10% PCL, by 2.09‐ and 3.30‐fold, respectively, as compared with uncoated CB‐HAp. However, coating with 10% PCL resulted in a reduction in porosity. Furthermore, an in vitro biological evaluation demonstrated that MG‐63 cells adhered well, proliferated and were able to be differentiated on the PCL‐coated CB‐HAp scaffold, which was noncytotoxic. These results suggest that a simple coating method is useful to improve the compressive strength of CB‐HAp for bone tissue engineering applications. © 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 101B: 1302–1309, 2013.