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Porous calcium polyphosphate as load‐bearing bone substitutes: In vivo study
Author(s) -
Pilliar Robert M.,
Kandel Rita A.,
Grynpas Marc D.,
Hu Youxin
Publication year - 2013
Publication title -
journal of biomedical materials research part b: applied biomaterials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.665
H-Index - 108
eISSN - 1552-4981
pISSN - 1552-4973
DOI - 10.1002/jbm.b.32832
Subject(s) - materials science , porosity , fixation (population genetics) , polyphosphate , calcium , biomedical engineering , femoral condyle , implant , in vivo , load bearing , biocompatibility , composite material , anatomy , chemistry , surgery , medicine , metallurgy , phosphate , cartilage , microbiology and biotechnology , organic chemistry , biology , biochemistry , gene
Porous calcium polyphosphate (CPP) is being investigated for fabrication of novel biodegradable bone substitutes. In this study, porous CPP implants formed by conventional CPP powder packing and using a two‐step sinter/anneal process was used to form 20 and 30 vol % porous samples displaying relatively high strength. These were implanted in rabbit femoral condyle sites to study their ability for secure fixation in prepared sites through bone ingrowth. Porous implants of 20 and 30 vol % porosity and displaying compressive strengths ∼80 and 35 MPa, respectively, were used. Bone ingrowth sufficient to allow secure implant fixation was observed by 6 weeks (∼19% bone ingrowth per available pore space for the 30 vol % and 13% for the 20 vol % porous implants). The results of the in vivo study suggest the potential usefulness of porous CPP as biodegradable bone substitutes/augments in high load‐bearing skeletal regions. © 2012 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 101B: 1–8, 2013.