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Human adipose‐derived stem cells and three‐dimensional scaffold constructs: A review of the biomaterials and models currently used for bone regeneration
Author(s) -
Zanetti Andrea S.,
Sabliov Cristina,
Gimble Jeffrey M.,
Hayes Daniel J.
Publication year - 2013
Publication title -
journal of biomedical materials research part b: applied biomaterials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.665
H-Index - 108
eISSN - 1552-4981
pISSN - 1552-4973
DOI - 10.1002/jbm.b.32817
Subject(s) - regeneration (biology) , scaffold , adipose tissue , stem cell , microbiology and biotechnology , biology , biomedical engineering , engineering , biochemistry
In the past decade, substantial strides have been taken toward the use of human adipose‐derived stromal/stem cells (hASC) in the regeneration of bone. Since the discovery of the hASC osteogenic potential, many models have combined hASC with biodegradable scaffold materials. In general, rats and immunodeficient (nude) mice models for nonweight bearing bone formation have led the way to assess hASC osteogenic potential in vivo . The goal of this review is to present an overview of the recent literature describing hASC osteogenesis in conjuction with three‐dimensional scaffolds for bone regeneration. © 2012 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 101B: 187–199, 2013.