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Silk fibroin particles as templates for mineralization of calcium‐deficient hydroxyapatite
Author(s) -
Choi Youngeun,
Cho Se Youn,
Park Doo Jin,
Park Hyun Ho,
Heo Semi,
Jin HyoungJoon
Publication year - 2012
Publication title -
journal of biomedical materials research part b: applied biomaterials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.665
H-Index - 108
eISSN - 1552-4981
pISSN - 1552-4973
DOI - 10.1002/jbm.b.32766
Subject(s) - fibroin , transmission electron microscopy , materials science , chemical engineering , zeta potential , scanning electron microscope , calcium , silk , polymer chemistry , composite material , nanotechnology , nanoparticle , metallurgy , engineering
Silk fibroin particles prepared by phase separation with polyethylene oxide were coated with calcium‐deficient hydroxyapatite (CDHA) crystals under various pH conditions. For different pH values, the growth and the morphology of CDHA crystals on the surface of silk fibroin particles were investigated in detail by zeta potential analysis, scanning electron microscopy, transmission electron microscopy, and X‐ray diffraction techniques. Negative charges formed by deprotonation of the functional groups on the surface of silk fibroin particles at high pH lead to an increase of binding affinity between the calcium ions of the CDHA crystals and the functional groups of the silk fibroin particles. Consequently, the generation of many CDHA crystals was promoted to deposit on the surface of silk fibroin particles at a high pH value. © 2012 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2012.