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Load‐bearing capacity and biological allowable limit of biodegradable metal based on degradation rate in vivo
Author(s) -
Cho Sung Youn,
Chae SooWon,
Choi Kui Won,
Seok Hyun Kwang,
Han Hyung Seop,
Yang Seok Jo,
Kim Young Yul,
Kim Jong Tac,
Jung Jae Young,
Assad Michel
Publication year - 2012
Publication title -
journal of biomedical materials research part b: applied biomaterials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.665
H-Index - 108
eISSN - 1552-4981
pISSN - 1552-4973
DOI - 10.1002/jbm.b.32722
Subject(s) - degradation (telecommunications) , ultimate tensile strength , materials science , alloy , microstructure , compression (physics) , compressive strength , bearing capacity , composite material , erosion , bending , tension (geology) , metallurgy , geotechnical engineering , telecommunications , paleontology , computer science , engineering , biology
In this study, a newly developed Mg‐Ca‐Zn alloy for low degradation rate and surface erosion properties was evaluated. The compressive, tensile, and fatigue strength were measured before implantation. The degradation behavior was evaluated by analyzing the microstructure and local hardness of the explanted specimen. Mean and maximum degradation rates were measured using micro CT equipment from 4‐, 8‐, and 16‐ week explants, and the alloy was shown to display surface erosion properties. Based on these characteristics, the average and minimum load bearing capacities in tension, compression, and bending modes were calculated. According to the degradation rate and references of recommended dietary intakes (RDI), the Mg‐Ca‐Zn alloy appears to be safe for human use. © 2012 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 100B: 1535–1544, 2012.