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Development of biodegradable polyurethane and bioactive glass nanoparticles scaffolds for bone tissue engineering applications
Author(s) -
de Oliveira Agda Aline Rocha,
de Carvalho Sandhra Maria,
de Fátima Leite Maria,
Oréfice Rodrigo Lambert,
de Magalhães Pereira Marivalda
Publication year - 2012
Publication title -
journal of biomedical materials research part b: applied biomaterials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.665
H-Index - 108
eISSN - 1552-4981
pISSN - 1552-4973
DOI - 10.1002/jbm.b.32710
Subject(s) - bioactive glass , materials science , biocompatibility , polyurethane , biopolymer , simulated body fluid , composite material , tissue engineering , nanoparticle , composite number , polymer , biomedical engineering , nanotechnology , scanning electron microscope , medicine , metallurgy
Abstract The development of polymer/bioactive glass has been recognized as a strategy to improve the mechanical behavior of bioactive glass‐based materials. Several studies have reported systems based on bioactive glass/biopolymer composites. In this study, we developed a composite system based on bioactive glass nanoparticles (BGNP), obtained by a modified Stöber method. We also developed a new chemical route to obtain aqueous dispersive biodegradable polyurethane. The production of polyurethane/BGNP scaffolds intending to combine biocompatibility, mechanical, and physical properties in a material designed for tissue engineering applications. The composites obtained were characterized by structural, biological, and mechanical tests. The films presented 350% of deformation and the foams presented pore structure and mechanical properties adequate to support cell growth and proliferation. The materials presented good cell viability and hydroxyapatite layer formation upon immersion in simulated body fluid. © 2012 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2012.