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Biocompatibility of polymethylmethacrylate resins used in dentistry
Author(s) -
Gautam Rupali,
Singh Raghuwar D.,
Sharma Vinod P.,
Siddhartha Ramashanker,
Chand Pooran,
Kumar Rakesh
Publication year - 2012
Publication title -
journal of biomedical materials research part b: applied biomaterials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.665
H-Index - 108
eISSN - 1552-4981
pISSN - 1552-4973
DOI - 10.1002/jbm.b.32673
Subject(s) - biocompatibility , dentistry , materials science , irritation , acrylic resin , dentures , biomedical engineering , biological safety , medicine , composite material , coating , immunology , metallurgy
Abstract Biocompatibility or tissue compatibility describes the ability of a material to perform with an appropriate host response when applied as intended. Poly‐methylmethacrylate (PMMA) based resins are most widely used resins in dentistry, especially in fabrication of dentures and orthodontic appliances. They are considered cytotoxic on account of leaching of various potential toxic substances, most common being residual monomer. Various in vitro and in vivo experiments and cell based studies conducted on acrylic based resins or their leached components have shown them to have cytotoxic effects. They can cause mucosal irritation and tissue sensitization. These studies are not only important to evaluate the long term clinical effect of these materials, but also help in further development of alternate resins. This article reviews information from scientific full articles, reviews, or abstracts published in dental literature, associated with biocompatibility of PMMA resins and it is leached out components. Published materials were searched in dental literature using general and specialist databases, like the PubMED database. © 2012 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2012.