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Chitosan as a barrier membrane material in periodontal tissue regeneration
Author(s) -
Xu Chun,
Lei Chang,
Meng Liuyan,
Wang Changning,
Song Yaling
Publication year - 2012
Publication title -
journal of biomedical materials research part b: applied biomaterials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.665
H-Index - 108
eISSN - 1552-4981
pISSN - 1552-4973
DOI - 10.1002/jbm.b.32662
Subject(s) - chitosan , cementum , regeneration (biology) , membrane , periodontal fiber , chitin , dental alveolus , tissue engineering , drug delivery , biomedical engineering , materials science , chemistry , dentistry , nanotechnology , dentin , medicine , microbiology and biotechnology , biochemistry , composite material , biology
Periodontal regeneration is defined as regeneration of the tooth‐supporting tissues including cementum, periodontal ligament, and alveolar bone. Guided tissue regeneration (GTR) has been demonstrated to be an effective technique to achieve periodontal regeneration. In the GTR procedures, various kinds of membranes play important roles. Chitosan, a deacetylated derivative of chitin, is biocompatible, biodegradable, and antimicrobial. It acts as hydrating agent and possesses tissue healing and osteoinducing effect. Chitosan can be easily processed into membranes, gels, nanofibers, beads, nanoparticles, scaffolds, and sponges forms and can be used in drug delivery systems. Here, we review the bioproperties of chitosan and report the progress of application of chitosan as membranes in GTR and guided bone regeneration (GBR), which indicates that chitosan could be a good substrate candidate as the materials for the GTR/GBR membranes. © 2012 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2012.