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Morphological and degradation studies of sirolimus‐containing poly(lactide‐ co ‐glycolide) discs
Author(s) -
Ro Andrew J.,
Falotico Robert,
Davé Vipul
Publication year - 2012
Publication title -
journal of biomedical materials research part b: applied biomaterials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.665
H-Index - 108
eISSN - 1552-4981
pISSN - 1552-4973
DOI - 10.1002/jbm.b.32510
Subject(s) - plga , solvent , sirolimus , nuclear chemistry , copolymer , dimethyl sulfoxide , materials science , chemistry , extraction (chemistry) , polyester , supercritical carbon dioxide , chemical engineering , polymer , polymer chemistry , chromatography , in vitro , organic chemistry , biochemistry , engineering
The effect of residual solvent and copolymer ratio on the in vitro degradation and drug release behavior of a bioabsorbable polymer/drug system was investigated in an effort to understand and develop the use of these excipients for controlled drug delivery devices. Sirolimus‐containing poly(lactide‐ co ‐glycolide) (PLGA) discs were fabricated by a solution‐casting method using dimethyl sulfoxide (DMSO) as the solvent. The residual DMSO was removed from a set of discs by supercritical carbon dioxide extraction, and reflections of crystalline sirolimus were observed in the wide‐angle X‐ray scattering profile observed after extraction. A correlation was not observed between the extent of drug crystallization and extraction conditions and copolymer ratio. Mass loss, molecular weight, and sirolimus release were monitored during an in vitro study of the oven‐dried neat PLGA, sirolimus‐containing PLGA, and extracted sirolimus‐containing PLGA discs during 56 days. The sirolimus‐containing PLGA discs with residual DMSO exhibited a faster sirolimus release rate compared to the extracted discs. The residual DMSO facilitated release of sirolimus. The discs that contained PLGA with higher glycolide content, particularly 50% glycolide, degraded faster and exhibited faster sirolimus release. © 2011 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2012.