Premium
Histopathologic host response to polypropylene‐based surgical mesh materials in a rat abdominal wall defect model
Author(s) -
Huber Alexander,
Boruch Alan V.,
Nieponice Alejandro,
Jiang Hongbin,
Medberry Christopher,
Badylak Stephen F.
Publication year - 2012
Publication title -
journal of biomedical materials research part b: applied biomaterials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.665
H-Index - 108
eISSN - 1552-4981
pISSN - 1552-4973
DOI - 10.1002/jbm.b.32503
Subject(s) - polypropylene , materials science , foreign body giant cell , composite number , polyurethane , scaffold , cellular infiltration , host response , composite material , biomedical engineering , medicine , pathology , inflammation , immune system , immunology
Composite polypropylene‐based surgical mesh materials including various synthetic polymers and naturally occurring biomaterials have been developed to ameliorate device‐associated inflammatory response and associated reduced compliance of pure polypropylene meshes. This study evaluated the histomorphologic response of three composite polypropylene‐based surgical meshes, Revive™, a polycarbonate polyurethane reinforced monofilamentous polypropylene scaffold, Assure™, a polycarbonate polyurethane reinforced monofilamentous polypropylene scaffold with a resorbable anti‐adhesion layer of lactide caprolactone copolymer, and Proceed™, a polypropylene mesh modified with oxidized cellulose, in a soft tissue repair model in the rat. The host inflammatory response and neotissue formation were evaluated by semiquantitative histologic scoring including the amount of cellular infiltration, angiogenesis, presence of multinucleate giant cells, fibrous connective tissue formation, and host neo‐extracellular matrix deposition for up to 26 weeks. All three composite surgical mesh materials showed good integration with host tissue as indicated by rapid cellular infiltration, abundant neo‐vascularization, minimal shrinkage, and the lack of visible mesh degradation. The devices elicited a similar inflammatory response and the presence of a mild foreign body response in spite of the different composition and morphology of these composite mesh materials. © 2011 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2012.