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Synthesis, self‐assembly, and cytotoxicity of well‐defined trimethylated chitosan‐ O ‐poly(ε‐caprolactone): Effect of chitosan molecular weight
Author(s) -
Zhang Haiwen,
Cai Guoqiang,
Tang Guping,
Wang Liqun,
Jiang Hongliang
Publication year - 2011
Publication title -
journal of biomedical materials research part b: applied biomaterials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.665
H-Index - 108
eISSN - 1552-4981
pISSN - 1552-4973
DOI - 10.1002/jbm.b.31851
Subject(s) - chitosan , micelle , polymer chemistry , cationic polymerization , caprolactone , copolymer , chemistry , aqueous solution , sodium dodecyl sulfate , cytotoxicity , solubility , amphiphile , nuclear chemistry , materials science , organic chemistry , polymer , in vitro , biochemistry
Structurally well‐defined trimethylated chitosan‐ O ‐poly(ε‐caprolactone) (TMC‐ O ‐PCL) was synthesized under mild homogeneous conditions, using sodium dodecyl sulfate‐dimethylated chitosan complex (SDC) as an organosoluble intermediate. The effect of chitosan molecular weight (MW) on the preparation, organosolubility, self‐assembly, and cytotoxicity of the copolymers was investigated. The copolymers with low‐MW chitosan backbone had improved solubility in common organic solvents. Spherical micelles with average diameter of 25–55 nm and uniform morphology were formed through self‐assembly of TMC‐ O ‐PCL in pH 7.4 PBS. When trimethylation degree of the copolymers was above 44%, the micelles could remain stable in neutral aqueous media. The critical aggregation concentration of TMC‐ O ‐PCL slightly increased with a decrease in the MW of chitosan backbone. The cytotoxicity of the cationic micelles could be suppressed by increasing PCL grafting levels, reducing trimethylation degree, and MW of the chitosan backbone. © 2011 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2011.