Premium
A novel alkali metals/strontium co‐substituted calcium polyphosphate scaffolds in bone tissue engineering
Author(s) -
Song Wei,
Wang Qiguang,
Wan Changxiu,
Shi Tong,
Markel David,
Blaiser Ralph,
Ren Weiping
Publication year - 2011
Publication title -
journal of biomedical materials research part b: applied biomaterials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.665
H-Index - 108
eISSN - 1552-4981
pISSN - 1552-4973
DOI - 10.1002/jbm.b.31847
Subject(s) - strontium , polyphosphate , nuclear chemistry , calcium , scanning electron microscope , materials science , inductively coupled plasma , bioceramic , apatite , field emission microscopy , chemistry , alkali metal , chemical engineering , mineralogy , nanotechnology , metallurgy , phosphate , organic chemistry , composite material , plasma , physics , engineering , quantum mechanics , diffraction , optics
Our purpose of this study is to develop potassium or sodium/strontium co‐substituted calcium polyphosphate (K/Sr‐CPP or Na/Sr‐CPP) bioceramics in application of bone repairing scaffold. The incorporation of K, Na, and Sr into CPP substrate via a calcining‐sintering process was confirmed by X‐ray diffractometry and inductively coupled plasma atomic emission spectroscopy. In vitro degradation study of co‐substituted CPP indicated the incorporation of alkali metal elements promoted the degradability of CPP, and the scanning electron microscope showed the apatite‐like minerals were precipitated on the surface of co‐substituted CPP. The compress resistant strength of co‐substituted CPP was elevated by dopants. The MTT assay and confocal laser‐scanning microscope on osteoblasts culturing with co‐substituted CPP showed no cytotoxicity. The cell proliferation on co‐substituted CPP was even better than others. Thus, this co‐substituted CPP bioceramics might have potential of applications in orthopedic field. © 2011 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2011.