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Clinical device‐related article evaluation of morphology and functions of a foldable capsular vitreous body in the rabbit eye
Author(s) -
Chen Jiajia,
Gao Qianying,
Liu Yaqin,
Ge Jian,
Cao Xianwu,
Luo Yan,
Huang Danping,
Zhou Gege,
Lin Shaofen,
Lin Jianxian,
To Chi Ho,
Siu Andrew W.
Publication year - 2011
Publication title -
journal of biomedical materials research part b: applied biomaterials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.665
H-Index - 108
eISSN - 1552-4981
pISSN - 1552-4973
DOI - 10.1002/jbm.b.31812
Subject(s) - rabbit (cipher) , materials science , morphology (biology) , silicone oil , silicone , biomedical engineering , proliferative vitreoretinopathy , ophthalmology , biology , retinal , retinal detachment , medicine , computer science , composite material , genetics , computer security
We previously proposed a new strategy to replace a vitreous body with a novel foldable capsular vitreous body (FCVB). In this study, the FCVB was designed to mimic natural vitreous morphology, and evaluate its physiological functions compared with traditional silicone oil substitutes, in an established rabbit model of proliferative vitreoretinopathy. We found that FCVB was a very good replacement for closely mimicking the morphology and restoring the physiological functions, such as the support, refraction, and cellular barriers, of the rabbit vitreous body. The study has provided us with a novel research and therapy strategy that could effectively mimic the morphology and physiological function of the rabbit vitreous body. © 2011 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2011.