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Preparation and properties of nano‐hydroxyapatite/PCL‐PEG‐PCL composite membranes for tissue engineering applications
Author(s) -
Fu Shao Zhi,
Wang Xiu Hong,
Guo Gang,
Shi Shuai,
Fan Min,
Liang Hang,
Luo Feng,
Qian Zhi Yong
Publication year - 2011
Publication title -
journal of biomedical materials research part b: applied biomaterials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.665
H-Index - 108
eISSN - 1552-4981
pISSN - 1552-4973
DOI - 10.1002/jbm.b.31788
Subject(s) - membrane , materials science , chemical engineering , fourier transform infrared spectroscopy , ethylene glycol , scanning electron microscope , composite number , contact angle , tissue engineering , ultimate tensile strength , nuclear chemistry , polymer chemistry , composite material , chemistry , biomedical engineering , medicine , engineering , biochemistry
Nano‐hydroxyapatite (n‐HA)/poly(ε‐caprolactone)‐poly(ethylene glycol)‐poly(ε–caprolactone) (PCL‐PEG‐PCL, PCEC) composite membranes were prepared by solvent casting and evaporation method. The structure and properties of the membranes were investigated by Fourier transform infrared spectroscopy (FT‐IR), X‐ray diffraction (XRD), scanning electron microscopy (SEM), water contact angle measurements, in vitro hydrolytic degradation, mechanical test, and cell culture. The effect of n‐HA content on physical–chemical properties of the n‐HA/PCEC composite membranes was studied. The results showed that the shape and size of micropores of the composite membranes changed with n‐HA content increased; the tensile strength decreased with the increase of n‐HA content. The osteoblast cell was cultured on the membranes, good cell attachment and growth manner were observed after postseeding for 1 day. MTT assays showed that the n‐HA/PCEC membranes had no negative effect on the cell viability and proliferation. These results suggested that the obtained n‐HA/PCEC composite membranes in this study might have prospective applications in tissue engineering field. © 2011 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2011.