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Hyaluronic acid nanofiber wound dressing—production, characterization, and in vivo behavior
Author(s) -
Uppal Rohit,
Ramaswamy Gita N.,
Arnold C.,
Goodband Robert,
Wang Y.
Publication year - 2011
Publication title -
journal of biomedical materials research part b: applied biomaterials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.665
H-Index - 108
eISSN - 1552-4981
pISSN - 1552-4973
DOI - 10.1002/jbm.b.31776
Subject(s) - vaseline , nanofiber , wound dressing , hyaluronic acid , materials science , bandage , adhesive , wound healing , biomedical engineering , surgery , composite material , medicine , anatomy , layer (electronics)
Hyaluronic acid (HA) was electrospun. The effects of flow rate, spin length, and the applied voltage on the diameter of the HA nanofibers were analyzed. The average thickness of the webs was 0.041 cm. The air permeability of sterilized HA nanofiber wound dressing was much higher than that of gauze with Vaseline. The degree of crystallinity of HA nanofibers was characterized using powder X‐ray technique and was found to be 20.6%. A preclinical study was conducted to compare healing of wounds covered by an adhesive bandage, a sterilized solid HA, gauze with Vaseline, an antibiotic dressing, and a sterilized HA nanofiber wound dressing. Results of the two methods of appraisal showed that the sterilized HA nanofiber wound dressing was the best type of dressing out of the five types of dressings compared. © 2011 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2011.