Premium
Inorganic coatings for cardiovascular stents: In vitro and in vivo studies
Author(s) -
Mikhalovska Lyuba,
Chortaliya,
Lazarenko Oleg,
Haworth Peter,
Sudre Arnaud,
Mikhalovsky Sergey
Publication year - 2011
Publication title -
journal of biomedical materials research part b: applied biomaterials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.665
H-Index - 108
eISSN - 1552-4981
pISSN - 1552-4973
DOI - 10.1002/jbm.b.31772
Subject(s) - materials science , neointima , coating , biocompatibility , in vivo , stent , biomedical engineering , diamond , composite material , metallurgy , restenosis , surgery , medicine , microbiology and biotechnology , biology
Abstract The in‐vitro and in‐vivo biocompatibility of two oxides (TiO and ZrO) and diamond‐like carbon (D) coated stents has been assessed and compared with uncoated stainless steel (St) stents. In vitro studies demonstrated that both fibrinogen adsorption and platelet adhesion were significantly higher on D coating compared to those on oxide coatings and uncoated stainless steel. In addition TiO and ZrO coatings showed evidence of a minor inflammatory response and more complete endothelialization of the aorta than that seen around D coated and uncoated St stents. The resulting neointimal growth in the aorta with TiO, ZrO, and D coated and uncoated St stents, measured 8 weeks after stenting (the ratio of the neointima in the stented artery to the non‐stented artery) was 1.03 + 0.28, 0.85 + 0.36, 1.78 + 1.26, and 1.15 + 0.56, accordingly. From the data obtained it could be concluded that the increased neointima measured around D‐coated stents, may be due to both, the inferior haemocompatibility of the diamond‐like carbon coating and mechanical instability of D coating observed in an in vivo environment. © 2010 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2011.