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Controllable dual‐release of dexamethasone and bovine serum albumin from PLGA/β‐tricalcium phosphate composite scaffolds
Author(s) -
Yang Yanfang,
Tang Gongwen,
Zhang Hong,
Zhao Yunhui,
Yuan Xubo,
Wang Min,
Yuan Xiaoyan
Publication year - 2011
Publication title -
journal of biomedical materials research part b: applied biomaterials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.665
H-Index - 108
eISSN - 1552-4981
pISSN - 1552-4973
DOI - 10.1002/jbm.b.31752
Subject(s) - plga , bovine serum albumin , controlled release , ethylene glycol , emulsion , nuclear chemistry , chemistry , materials science , polymer chemistry , chromatography , chemical engineering , in vitro , organic chemistry , biochemistry , nanotechnology , engineering
Abstract Localized dual‐drug delivery from biodegradable scaffolds is an important strategy in tissue engineering. In this study, porous poly( L ‐lactide‐ co ‐glycolide) (PLGA)/β‐tricalcium phosphate scaffolds containing both dexamethasone (Dex) and bovine serum albumin (BSA) were prepared by incorporating Dex‐loaded and BSA‐loaded microspheres into the scaffolds. PLGA microspheres containing Dex or BSA were prepared by spray‐drying and double emulsion/solvent evaporation, respectively. In vitro release studies indicated that microspheres prepared from PLGA in 3:1 molar ratio of L ‐lactide/glycolide and 89.5 kDa relative molecular mass showed prolonged release profiles compared with those prepared from PLGA in 1:1 L ‐lactide/glycolide molar ratio and 30.5 kDa relative molecular mass. Additionally, introduction of poly(ethylene glycol) in the PLGA chain could improve the encapsulation efficiency and reduce the release rate. Based on the above results, controllable dual‐release of Dex and BSA with relatively higher or lower release rate was achieved by incorporating Dex‐loaded and BSA‐loaded microspheres with different release profiles into the PLGA/β‐tricalcium phosphate scaffolds. © 2010 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2011.