Premium
Evaluation of magnesium ions release, biocorrosion, and hemocompatibility of MAO/PLLA‐modified magnesium alloy WE42
Author(s) -
Lu Ping,
Cao Lu,
Liu Yin,
Xu Xinhua,
Wu Xiangfeng
Publication year - 2011
Publication title -
journal of biomedical materials research part b: applied biomaterials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.665
H-Index - 108
eISSN - 1552-4981
pISSN - 1552-4973
DOI - 10.1002/jbm.b.31744
Subject(s) - biocompatibility , materials science , magnesium , magnesium alloy , corrosion , dielectric spectroscopy , coating , chemical engineering , lactic acid , metallurgy , electrochemistry , composite material , biomedical engineering , electrode , chemistry , medicine , biology , bacteria , engineering , genetics
Magnesium alloys may potentially be applied as biodegradable metallic materials in cardiovascular stent. However, the high corrosion rate hinders its clinical application. In this study, a new approach was adopted to control the corrosion rate by fabricating a biocompatible micro‐arc oxidation/poly‐ L ‐lactic acid (MAO/PLLA) composite coating on the magnesium alloy WE42 substrate and the biocompatibility of the modified samples was investigated. The scanning electronic microscope (SEM) images were used to demonstrate the morphology of the samples before and after being submerged in hanks solution for 4 weeks. The degradation was evaluated through the magnesium ions release rate and electrochemical impedance spectroscopy (EIS) test. The biocompatibility of the samples was demonstrated by coagulation time and hemolysis behavior. The result shows that the poly‐ L ‐lactic acid (PLLA) effectively improved the corrosion resistance by sealing the microcracks and microholes on the surface of the MAO coating. The modified samples had good compatibility. © 2010 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2011.