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In vitro performance assessment of new brushite‐forming Zn‐ and ZnSr‐substituted β‐TCP bone cements
Author(s) -
Pina S.,
Vieira S.I.,
Torres P. M. C.,
GoetzNeunhoeffer F.,
Neubauer J.,
da Cruz e Silva O. A. B.,
da Cruz e Silva E. F.,
Ferreira J. M. F.
Publication year - 2010
Publication title -
journal of biomedical materials research part b: applied biomaterials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.665
H-Index - 108
eISSN - 1552-4981
pISSN - 1552-4973
DOI - 10.1002/jbm.b.31669
Subject(s) - brushite , cement , bone cement , materials science , resazurin , rietveld refinement , nuclear chemistry , mineralogy , chemical engineering , composite material , chemistry , metallurgy , crystallography , crystal structure , calcium , biochemistry , engineering
The present study investigated the in vitro performance of brushite‐forming Zn‐ and ZnSr‐substituted β‐TCP bone cements in terms of wet mechanical strength and biological response. Quantitative phase analysis and structural refinement of the powdered samples were performed by X‐ray powder diffraction and Rietveld refinement technique. Initial and final setting times of the cement pastes, measured using Gilmore needles technique, showed that ZnSrCPC sets faster than ZnCPC. The measured values of the wet strength after 48 h of immersion in PBS solution at 37°C showed that ZnSrCPC cements are stronger than ZnCPC cements. Human osteosarcoma‐derived MG63 cell line proved the nontoxicity of the cement powders, using the resazurin metabolic assay. © 2010 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2010.