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Polymer coating of porcine decellularized and cross‐linked aortic grafts
Author(s) -
Heidenhain Christoph,
Weichert Wilko,
Schmidmaier Gerhard,
Wildemann Britt,
Hein Moritz,
Neuhaus Peter,
Heise Michael
Publication year - 2010
Publication title -
journal of biomedical materials research part b: applied biomaterials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.665
H-Index - 108
eISSN - 1552-4981
pISSN - 1552-4973
DOI - 10.1002/jbm.b.31650
Subject(s) - decellularization , coating , biomedical engineering , biocompatibility , medicine , transplantation , heparin , materials science , surgery , tissue engineering , composite material , metallurgy
This article investigates a method of modifying and optimizing the biocompatibility of decellularized vascular bioimplants when treated with a specialized, drug eluting coating. For this purpose, we carried out aortic transplantations using a porcine model. Decellularized, cross‐linked aortic grafts were coated with poly( D , L ‐lactide) (PDLLA). To this coating, we added the anticoagulant drug lepirudin which, following transplantation, would be linearly eluted. These aortic grafts are easily manipulated in surgery. It was shown that, as a result of the lepirudin‐eluting coating, the rate of thrombogenesis was reduced and the patency rate was significantly improved. However, lumen‐stenosing pseudointima developed in all of the transplants and was not effected by PDLLA coating. Furthermore, no evidence of recellularisation was documented. This trial demonstrates that polymer coating of decellularized tissue is possible. Neointimal hyperplasia and the absence of cellular repopulation mark the negative consequences of this concept. © 2010 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2010.