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Fluoropassivation and gelatin sealing of polyester arterial prostheses to skip preclotting and constrain the chronic inflammatory response
Author(s) -
Xie Xingyi,
Guidoin Robert,
Nutley Mark,
Zhang Ze
Publication year - 2010
Publication title -
journal of biomedical materials research part b: applied biomaterials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.665
H-Index - 108
eISSN - 1552-4981
pISSN - 1552-4973
DOI - 10.1002/jbm.b.31609
Subject(s) - gelatin , materials science , coating , polyester , composite material , polyethylene terephthalate , polytetrafluoroethylene , crystallinity , fluoropolymer , biomedical engineering , chemical engineering , chemistry , polymer , organic chemistry , medicine , engineering
Fluoropassivation and gelatin coating have been applied to polyethylene terephthalate (PET) vascular prosthesis to combine the advantages of both polytetrafluoroethylene (PTFE) and PET materials, and to eliminate the preclotting procedure. The morphological, chemical, physical, and mechanical properties of such prostheses were investigated and compared with its original model. Fluoropassivation introduced OCF 3 , CF 3 , and CFCF 2 structures onto the surface of the polyester fibers. However, the surface fluorine content was only 28–32% compared to the 66% in expanded PTFE (ePTFE) grafts. The fluoropassivation decreased the hydrophilicity, slightly increased the water permeability, and marginally lowered the melting point and the crystallinity of the PET fibers. After gelatin coating, the fluoropassivated and nonfluoropassivated prostheses showed similar surface morphology and chemistry. While gelatin coating eliminated preclotting, it also renders the prostheses slightly stiffer. The original prosthesis had the highest bursting strength (275 N), with the fluoropassivated and gelatin‐sealed devices showing similar bursting strength between 210 and 230 N. Fluoropassivation and gelatin coating lowered the retention strength by 23 and 30% on average, respectively. In vitro enzymatic incubation had only marginal effect on the surface fluorine content of the nongelatin‐sealed prostheses. However, the gelatin‐sealed ones significantly lost their surface fluorine after in vitro enzymatic incubation (by 69–85%) or in vivo 6‐month implantation (by 51–60%), showing the lability of the fluoropolymer layer under the hostile biological environment. © 2010 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2010