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The effect of water on particle size, porosity and the rate of drug release from implanted titania reservoirs
Author(s) -
Lopez Tessy,
Ortiz Emma,
AlexanderKatz Roberto,
Odriozola Jose A.,
Quintana Patricia,
Gonzalez Richard D.,
Lottici Pier Paolo,
Marino Iari G.
Publication year - 2010
Publication title -
journal of biomedical materials research part b: applied biomaterials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.665
H-Index - 108
eISSN - 1552-4981
pISSN - 1552-4973
DOI - 10.1002/jbm.b.31595
Subject(s) - porosity , agglomerate , particle size , materials science , chemical engineering , titanium , particle (ecology) , sol gel , kinetics , valproic acid , dissolution , oxide , hydroxylation , hydrolysis , nuclear chemistry , chemistry , organic chemistry , composite material , nanotechnology , metallurgy , quantum mechanics , neuroscience , epilepsy , engineering , biology , enzyme , geology , oceanography , physics
The implantation of controlled drug release devices represents a new strategy in the treatment of neurodegenerative disorders. Sol–gel titania implants filled with valproic acid, have been used for this purpose to treat induced epilepsy in rats. The kinetics of the drug release depend on: (a) porosity, (b) chemical interactions between valproic acid and surface hydroxyl groups of titania, (c) particle size, and (d) particle size agglomerates. The concentration of water used in the hydrolysis reaction is an important variable in the degree of porosity, hydroxylation, and structural defects of the nanostructured titanium oxide reservoir. The titanium n ‐butoxide/water ratio was systematically varied during the sol–gel synthesis, while maintaining the amount of valproic acid constant. Characterization studies were performed using DTA‐TGA, FTIR, Raman, TEM, SEM, BET, and in vitro release kinetic measurements. The particle agglomerate size and porosity were found to depend on the amount of water used in the sol–gel reaction. © 2010 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2010