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Biodegradable poly(α‐hydroxy acid) polymer scaffolds for bone tissue engineering
Author(s) -
Yu Nicole Y. C.,
Schindeler Aaron,
Little David G.,
Ruys Andrew J.
Publication year - 2010
Publication title -
journal of biomedical materials research part b: applied biomaterials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.665
H-Index - 108
eISSN - 1552-4981
pISSN - 1552-4973
DOI - 10.1002/jbm.b.31588
Subject(s) - scaffold , tissue engineering , biomedical engineering , biodegradation , biomaterial , materials science , biodegradable polymer , polymer , chemistry , engineering , organic chemistry , composite material
Synthetic graft materials are emerging as a viable alternative to autogenous bone graft and bone allograft for the treatment of critical‐sized bone defects. These materials can be osteoconductive but are rarely intrinsically osteogenic, although this can be greatly enhanced by the application of bone morphogenetic proteins (BMPs). This review will discuss the versatility of biodegradable poly(α‐hydroxy acids) for the delivery of BMPs for bone tissue engineering. Poly(α‐hydroxy acids) have a considerable potential for customization and adaptability via modification of design parameters, including scaffold architecture, composition, and biodegradability. Different fabrication techniques will also be discussed. © 2010 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2010