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Synthesis, in vitro hydroxyapatite forming ability, and cytocompatibility of strontium silicate powders
Author(s) -
Zhang Meili,
Zhai Wanyin,
Lin Kaili,
Pan Haobo,
Lu William,
Chang Jiang
Publication year - 2010
Publication title -
journal of biomedical materials research part b: applied biomaterials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.665
H-Index - 108
eISSN - 1552-4981
pISSN - 1552-4973
DOI - 10.1002/jbm.b.31582
Subject(s) - strontium , simulated body fluid , apatite , strontium carbonate , in vitro , nuclear chemistry , silicate , precipitation , materials science , chemical engineering , ionic bonding , regeneration (biology) , chemistry , mineralogy , ion , biochemistry , organic chemistry , biology , microbiology and biotechnology , physics , meteorology , engineering
Phase‐pure strontium silicate (SrSiO 3 ) powders were synthesized by chemical precipitation method. In vitro bioactivity of the powders were evaluated by examining the hydroxyapatite forming ability on their surface soaking simulated body fluid for various periods. The results showed that SrSiO 3 could induce hydroxy carbonate apatite formation after soaking for 7 days. Both L929 and rabbit bone marrow stromal cells (rMSCs) were used to test the in vitro cytocompatibility of SrSiO 3 . L929 culture experiment showed that the ionic product of SrSiO 3 did not exhibit cytotoxicity except at high ion concentrations (Si 3.75 m M and Sr 0.12 m M ). Moreover, at certain ion concentrations (Si 1.87–0.12 m M and Sr 0.12–3.75 × 10 −3 m M ), the ionic product of SrSiO 3 stimulated the proliferation of rMSCs. All the results indicated that SrSiO 3 might be used as a new bioactive material for bone regeneration applications. © 2010 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2010