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Formulation and characterization of radio‐opaque conjugated in situ gelling materials
Author(s) -
Blakely Brandon,
Hoon Lee Bae,
Riley Celeste,
McLemore Ryan,
Pathak Chandrashekhar P.,
Ver Brent L.
Publication year - 2010
Publication title -
journal of biomedical materials research part b: applied biomaterials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.665
H-Index - 108
eISSN - 1552-4981
pISSN - 1552-4973
DOI - 10.1002/jbm.b.31539
Subject(s) - ethylene glycol , pentaerythritol , acrylate , methyl acrylate , polymer chemistry , materials science , polyethylene glycol , ethyl acrylate , reaction rate constant , nuclear chemistry , chemistry , copolymer , polymer , organic chemistry , kinetics , composite material , physics , quantum mechanics , fire retardant
X‐ray visibility is an integral design component of in situ gelling embolization systems for neurovascular treatment. The goals of this project included the synthesis and characterization of a unique intrinsically radio‐opaque in situ gelling material for neurovascular embolization. The gels formed using Michael‐Type Addition between pentaerythritol tetrakis 3‐mercaptopropionate (QT) thiols and poly(propylene glycol) diacrylate (PPODA) with the addition of the new material Iodobenzoyl poly(ethylene glycol) acrylate (IPEGA), a radio‐opaque agent, synthesized successfully as confirmed with 1 H NMR. The PPODA and IPEGA were mixed using a syringe coupler with QT and buffer at pH 11 for 90 seconds. Gel mixes were weighed to provide equal molar thiols and acrylate groups, changing the present acrylate‐bearing compounds wt % ratios from 100 PPODA: 0 IPEGA, 90:10, 80:20, 70:30, 60:40, 50:50, and 0:100. Formulations with 10% and above of IPEGA were X‐ray visible. Rheology showed that increasing the amount of IPEGA decreased the storage. Kinetic FT‐IR studies indicate that the amphiphilic nature of the PEG backbone increased the reaction rate of the phase segregated reactants. Second order reaction constant modeling showed a change in initial reaction rate from 0.0029 to 0.0187 (M sec) −1 from the 10% to 50% IPEGA formulations respectively. © 2010 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2010