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Toxicity evaluation of biodegradable and thermosensitive PEG‐PCL‐PEG hydrogel as a potential in situ sustained ophthalmic drug delivery system
Author(s) -
Yin HongBo,
Gong ChangYang,
Shi Shuai,
Liu XuYang,
Wei YuQuan,
Qian ZhiYong
Publication year - 2010
Publication title -
journal of biomedical materials research part b: applied biomaterials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.665
H-Index - 108
eISSN - 1552-4981
pISSN - 1552-4973
DOI - 10.1002/jbm.b.31498
Subject(s) - ethylene glycol , drug delivery , peg ratio , copolymer , biocompatible material , self healing hydrogels , biodegradation , chemistry , materials science , biomedical engineering , polymer chemistry , nanotechnology , polymer , medicine , organic chemistry , finance , economics
In this work, a biodegradable poly(ethylene glycol)‐poly(ε‐caprolactone)‐poly (ethylene glycol) (PEG‐PCL‐PEG, PECE) triblock copolymer was successfully synthesized, which was flowing sol at low temperature and turned to nonflowing gel at body temperature. The toxicity evaluation of PECE hydrogel as a potential in situ sustained opthalmic drug delivery system was performed, including the biodegradability of PECE hydrogel in the eye, its effect on cultured human lens epithelia, intraocular pressure, and ocular tissues. The results indicated that the prepared PECE hydrogel was biocompatible and biodegradable despite of temporary elevated intraocular pressure and slight corneal endothelial damage at specific concentration. Therefore, PECE hydrogel may be a safe candidate for sustained ophthalmic drug delivery system. © 2009 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 2010