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Intermittent watt‐level ultrasonication facilitates vancomycin release from therapeutic acrylic bone cement
Author(s) -
Cai XunZi,
Chen XianZhen,
Yan ShiGui,
Ruan ZouRong,
Yan RuiJian,
Ji Kang,
Xu Jia
Publication year - 2009
Publication title -
journal of biomedical materials research part b: applied biomaterials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.665
H-Index - 108
eISSN - 1552-4981
pISSN - 1552-4973
DOI - 10.1002/jbm.b.31288
Subject(s) - sonication , vancomycin , biomedical engineering , materials science , petri dish , composite material , chromatography , dentistry , chemistry , microbiology and biotechnology , medicine , biology , staphylococcus aureus , bacteria , genetics
Ultrasound holds promise for enhancing the vancomycin release from cement though the length of time when local drug level exceeded the minimum inhibitory concentration ( T >MIC ) was not prolonged by the previous protocol of milliwatt‐level ultrasonication. Here vancomycin‐loaded cements were subjected to continuous watt‐level ultrasonication (CUG), intermittent watt‐level ultrasonication (IUG) or no ultrasonication (NUG) for 14 d during immersion in 40‐ml phosphate buffered saline (PBS) for 28 d. The T >MIC for IUG was more than three times that for NUG. In contrast, T >MIC for CUG was slightly shortened. The subtherapeutic release of vancomycin between 15 d and 28 d for IUG was one‐ninth that for NUG. The fitting equations indicated a significant enhancement on the burst release and the slow release for IUG; however, the continuous ultrasonication hampered the slow release. SEM images exhibited denser craters and pores with larger diameters and less residual drug in specimens from IUG relative to those from both CUG and NUG. Intermittent watt‐level ultrasonication improved the ultrasound‐enhanced vancomycin release from cement in view of the prolonged T >MIC and the inhibited subtherapeutic release compared with continuous ultrasonication. The mechanisms may be associated with the distinctive effects of detaching forces and pushing forces by acoustic microstreams. © 2008 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2009

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