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Enhancement of antibiotic elution from acrylic bone cement
Author(s) -
Anagnostakos Konstantinos,
Kelm Jens
Publication year - 2009
Publication title -
journal of biomedical materials research part b: applied biomaterials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.665
H-Index - 108
eISSN - 1552-4981
pISSN - 1552-4973
DOI - 10.1002/jbm.b.31281
Subject(s) - materials science , elution , bone cement , antibiotics , cement , biomedical engineering , antimicrobial , drug , dentistry , composite material , chromatography , pharmacology , medicine , microbiology and biotechnology , chemistry , biology
Antibiotic‐loaded acrylic bone cement is a well‐established tool in the prophylaxis and treatment of orthopedic infections. Numerous studies about its pharmacokinetic properties have demonstrated that only a small part of the incorporated antibiotic amounts can be released, mostly over the first 8–10 weeks. Therefore, in the past 10 years, several attempts have been made for enhancement of the drug elution from bone cement. This article reviews this experience and pays special attention on biantibiotic combinations, additives other than antimicrobial agents, as well as the effect of ultrasound on the antibiotic elution characteristics. © 2009 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2009