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In vivo study effect of particulate Bioglass® in the prevention of infection in open fracture fixation
Author(s) -
Xie ZongPing,
Zhang ChangQing,
Yi ChengQing,
Qiu JianJun,
Wang JianQiang,
Zhou Juan
Publication year - 2009
Publication title -
journal of biomedical materials research part b: applied biomaterials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.665
H-Index - 108
eISSN - 1552-4981
pISSN - 1552-4973
DOI - 10.1002/jbm.b.31273
Subject(s) - staphylococcus aureus , in vivo , fixation (population genetics) , medicine , staphylococcus , negative control , infection rate , in vitro , surgery , dentistry , biology , bacteria , microbiology and biotechnology , traditional medicine , population , genetics , environmental health , biochemistry
There are many in vitro experiments showing that particulate bioactive glasses have a broad and certain antibacterial effect, but there is no report about this antibacterial effect in vivo so far. The aim of this study is to examine the efficacy of particulate Bioglass® in reducing the rate of infection with Staphylococcus aureus after the fixation of open tibial fractures in rabbits. The test in vivo was carried out with male rabbits split into two groups infected with Staphylococcus aureus at the right tibial fracture sites fixed with plate and screw, either with or without bioactive glass respectively. Culture results show that six of ten rabbits from the control group had a positive culture for the strain of Staphylococcus aureus ATCC25923, compared with six of the nine rabbits from the Bioglass® group. The median radiographic score is 4.5 points for the rabbits from the control group and 4 points for the rabbits from the Bioglass® group. The median histopathological score was 2.5 points for the rabbits in the control group and 3 points for the rabbits in the Bioglass® group. In conclusion, this study showed no significant difference between the rates of infection of two groups. Particulate Bioglass® did not reduce the rate of infection with Staphylococcus aureus after the fixation of open tibial fractures in rabbits. © 2008 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2009