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Characterization and cytocompatibility of nano‐hydroxyapatite/chitosan bone cement with the addition of calcium salts
Author(s) -
Zou Qin,
Li Yubao,
Zhang Li,
Zuo Yi,
Li Junfeng,
Li Xiaoyu
Publication year - 2009
Publication title -
journal of biomedical materials research part b: applied biomaterials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.665
H-Index - 108
eISSN - 1552-4981
pISSN - 1552-4973
DOI - 10.1002/jbm.b.31267
Subject(s) - compressive strength , cement , materials science , wetting , chitosan , contact angle , composite material , bone cement , calcium , calcium carbonate , composite number , calcium oxide , chemical engineering , metallurgy , engineering
In the present study, a calcium carbonate and calcium oxide loaded nano‐hydroxyapatite/chitosan bone cement was developed and its in vitro cell responses were investigated. The physico‐chemical properties were represented in terms of setting time, compressive strength, and wettability. The results show that the setting time is about 15 min, the compressive strength is up to 17.80 ± 0.45 MPa throughout the immersion period, and the static contact angle of the cement against water is 33.5° ± 2.7°, indicating that the cement has good setting time, compressive strength, and wettability. Cytocompatibility test using human MG63 cells reveals a favorable cell viability and increased proliferation over a period of 11 days in culture. The composition and hydrophilic nature of the cement provide a friendly environment for the attachment and growth of cells. The novel composite bone cement could be useful in moderate stress‐bearing applications of bone repair. © 2008 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2009