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Potential of chemically modified hydrophilic surface characteristics to support tissue integration of titanium dental implants
Author(s) -
Schwarz Frank,
Wieland Marco,
Schwartz Zvi,
Zhao Ge,
Rupp Frank,
GeisGerstorfer Jürgen,
Schedle Andreas,
Broggini Nina,
Bornstein Michael M.,
Buser Daniel,
Ferguson Stephen J.,
Becker Jürgen,
Boyan Barbara D.,
Cochran David L.
Publication year - 2009
Publication title -
journal of biomedical materials research part b: applied biomaterials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.665
H-Index - 108
eISSN - 1552-4981
pISSN - 1552-4973
DOI - 10.1002/jbm.b.31233
Subject(s) - titanium , osseointegration , wetting , materials science , dental implant , surface modification , implant , biomedical engineering , nanotechnology , chemical engineering , dentistry , metallurgy , composite material , surgery , medicine , engineering
In the past, several modifications of specific surface properties such as topography, structure, chemistry, surface charge, and wettability have been investigated to predictably improve the osseointegration of titanium implants. The aim of the present review was to evaluate, based on the currently available evidence, the impact of hydrophilic surface modifications of titanium for dental implants. A surface treatment was performed to produce hydroxylated/hydrated titanium surfaces with identical microstructure to either acid‐etched, or sand‐blasted, large grit and acid‐etched substrates, but with hydrophilic character. Preliminary in vitro studies have indicated that the specific properties noted for hydrophilic titanium surfaces have a significant influence on cell differentiation and growth factor production. Animal experiments have pointed out that hydrophilic surfaces improve early stages of soft tissue and hard tissue integration of either nonsubmerged or submerged titanium implants. This data was also corroborated by the results from preliminary clinical studies. In conclusion, the present review has pointed to a potential of hydrophilic surface modifications to support tissue integration of titanium dental implants. © 2008 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2009